![]() While both low and high-frequency (including theta burst), left and right temporo-parietal sites have been used as paradigms, low-frequency stimulation of left hemisphere has been found to be common as well as comparatively effective. īrain stimulation techniques, especially repetitive transcranial magnetic stimulation (rTMS) have been found to be effective in reducing frequency and duration of AVH. Among the non pharmacological strategies, psychological therapies have been found to be effective in reducing their burden but not able to cause much dent in frequency or duration. However, about 25% to 30% of patients who experience AVH have been found to be unresponsive to antipsychotic medication. While more than 60% of patients with schizophrenia present with AVH, majority of them respond usually to antipsychotic regimens. Add on priming however, seems to be particularly better in faster reduction in loudness of AVH.Īuditory verbal hallucinations (AVH) are among the commonly presenting positive symptoms in patients of schizophrenia. We conclude that low-frequency rTMS alone and high-frequency priming of low-frequency rTMS do not elicit significant differences in treatment of overall psychopathology, particularly AVH when given in recent onset schizophrenia patients. We found no difference between the two groups on all measures, except for significantly greater improvement on loudness of AVH in the group with priming stimulation during the follow-ups (F = 2.72 p < .05). baseline through 1, 2, 4 and 6 weeks) in both the treatment groups. ![]() We found that all the scores of these ratings significantly reduced over time (i.e. The severity of AVH and other psychotic symptoms were assessed with the auditory hallucination subscale (AHRS) of the Psychotic Symptom Rating Scales (PSYRATS), the Positive and Negative Syndrome Scale (PANSS) and the Clinical Global Impression (CGI). Both treatments were directed at the left temporo-parietal region. Patients were randomized over two groups: one receiving low-frequency rTMS preceded by priming and another receiving low-frequency rTMS without priming. Methodsįorty recent onset schizophrenia patients completed the study. The aim of this randomized controlled study was to investigate whether the effects of rTMS on AVH can be enhanced with priming rTMS in recent onset schizophrenia patients. However, this technique has not been investigated in recent onset schizophrenia patients. ![]() Priming stimulation, which involves high-frequency rTMS stimulation followed by low-frequency rTMS, has been shown to markedly enhance the neural response to the low-frequency stimulation train. Repetitive transcranial magnetic stimulation (rTMS) has been found to be effective in reducing frequency and duration of auditory verbal hallucinations (AVH).
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